Free classroom resources for teaching gel electrophoresis
Tuesday, October 21, 2025
Gel electrophoresis is a foundational tool in molecular biology labs. Although the process can seem mysterious at first, the right visual explanations and hands-on narratives can make the technique come alive for students.
To support biology instructors introducing this core biotechnology skill, we’ve collected four free resources that make gel electrophoresis more approachable, visual, and intuitive for first-time learners.
1. Microbe Hunters Digital Lab: Using electrophoresis to track down pathogens
In Microbe Hunters Digital, students step into the role of researchers working with astronauts aboard the International Space Station (ISS). After collecting samples from potential hotspots on the station, they use PCR and gel electrophoresis to determine whether harmful bacteria are hiding in plain sight.
In Microbe Hunters, students use electrophoresis to monitor the ISS for dangerous microbes.
As they carry out this investigation, students learn how gel electrophoresis separates DNA fragments and how band patterns can be used to identify unknown microbes. The lab also illustrates how gels work alongside PCR to transform invisible DNA into interpretable data.
Key features include:
- Interactive animations that unpack molecular mechanisms
- Narration from astronauts and laboratory scientists
- Auto-graded questions
- Completely free to access
Learn more about Microbe Hunters.
This virtual investigation can serve as a standalone experience or as a companion to the Microbe Hunters Learning Lab™ hands-on kit.
2. "What is Gel Electrophoresis?" video
This short, student-friendly explainer covers the science underlying gel electrophoresis, walks through the practicalities of setting up an electrophoresis experiment, and explains how to interpret results. Technical concepts are illustrated through engaging animations that clarify difficult concepts for students.
Teachers often use this resource as a warm-up before starting a lab or as a visual aid when students are interpreting results for the first time.
3. Introduction to Gel Electrophoresis reading
This brief reading provides a concise and approachable overview of gel electrophoresis. It explains how DNA moves through a gel, why different-sized fragments travel at different speeds, and how band patterns can be used to answer scientific questions.
Because it is short, clear, and visually supported, this resource works well as pre-lab reading, homework, or reinforcement after students complete an electrophoresis lab.
4. Gel Electrophoresis Basics Worksheet
Designed to support student understanding, this worksheet guides learners through the core ideas behind gel electrophoresis. It asks them to connect what they learned from the video and reading to real examples of how gels separate DNA and how scientists interpret the resulting patterns.
The Gel Electrophoresis Basics Worksheet
Download the Gel Electrophoresis Basics Worksheet (PDF) here.
Teachers often use this worksheet as individual practice or homework assignment prior to completing an electrophoresis lab.
Bring gel electrophoresis to life for your students
Whether you’re preparing learners for hands-on work, teaching a fully virtual course, or introducing gel electrophoresis for the first time, these free resources can help students build a clear and confident understanding of this fundamental biotechnology technique.
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